Explore testosterone research on muscle size, lean mass, strength and physical function. These outcomes and the populations studied are not interchangeable.
Selected from the completed-summary collection, not a systematic review or exhaustive literature search. Human reports appear first; reviews and preclinical work retain their labels.
Human · 2001-12-01
A randomized dose-response experiment compared five testosterone-enanthate groups over 20 weeks after suppressing participants' natural testosterone production. Energy and protein intake were standardized.
No author-stated limitations were available in the abstract. This was a 20-week experiment with experimentally suppressed natural testosterone, rather than an untreated comparison.
Human · 1996-07-01
Randomized trial comparing weekly testosterone enanthate or placebo, each with or without standardized resistance training.
This was a small, 10-week study in normal men using a supraphysiologic regimen. The abstract reports mood and behavior but no longer-term safety assessment or author-stated limitations.
Human · 2004-11-23
A randomized, double-blind human trial tested testosterone dose responses, with comparison against previously studied younger men.
The age comparison used previous younger-men data rather than concurrent age groups. No author-stated limitation was available in this abstract.
Review · 2010-06-01
This Endocrine Society clinical-practice guideline addressed evaluation and treatment of androgen-deficiency syndromes in adult men.
The panel advised against starting therapy with breast or prostate cancer, high hematocrit, severe untreated sleep apnea, severe urinary symptoms, or poorly controlled heart failure.