PED EVIDENCE · LONG READS
Deeper reads on the research behind performance and health.
Women’s health · Androgens & outcomes
Human testosterone studies in women: low desire, muscle and performance, cognitive null findings, SHBG, exposure differences and meaningful safety uncertainties.
Read the articleNeuropeptides · Brain & behavior
Semax and Selank: BDNF and GABA hypotheses, nasal delivery, historical human anxiety and stroke studies, safety and the limits of focus claims.
Read the articlePerformance nutrition · Muscle & brain
Creatine monohydrate, ATP buffering, muscle growth and cognition: human trials, early water changes, sleep deprivation, null results and kidney-marker interpretation.
Read the articleAndrogens · Blood & iron
Testosterone, erythropoietin, hepcidin and iron: what hematocrit measures, how human trials explain the rise, and what blood removal has and has not proved.
Read the articlePeptides · Gut inflammation & delivery
KPV, PepT1 and intestinal inflammation: cell mechanisms, mouse colitis experiments, targeted oral formulations, human evidence gaps and safety uncertainty.
Read the articleAndrogen signaling · Muscle & selectivity
LGD-4033 and enobosarm: receptor selectivity, human lean-mass and function trials, hormonal and liver signals, product identity and current development.
Read the articleVascular signaling · Muscle & metabolism
Follow tadalafil from NO and cGMP signaling to human glucose studies, lean-mass findings and muscle-cell experiments. What supports hypertrophy, and what remains unproved?
Read the articleAAS · Cardiac function & recovery
A visual guide to anabolic steroids and the heart: the 2026 follow-up study, cardiac remodeling, ejection fraction, coronary flow and the limits of recovery claims.
Read the articleNNMT · Metabolism & translation
How 5-amino-1MQ targets NNMT: NAD salvage, methyl donors, mouse fat-loss studies, tissue exposure, aging muscle and the untested NAD+/MOTS-c combination.
Read the articleAndrogens · Mechanisms & translation
A visual deep dive into trenbolone: androgen receptors, protein synthesis and breakdown, satellite cells, animal muscle growth, human safety signals and the limits of extrapolation.
Read the articleExercise mimetics · Preclinical evidence
A visual evidence guide to SLU-PP-332: ERR signaling, oxidative muscle fibers, mouse endurance and metabolic findings, human-derived cells, exposure limits and the distinction from SLU-PP-915.
Read the articleUrolithin A · Mitochondria & human performance
Urolithin A and muscle performance: mitophagy, randomized human strength and endurance trials, primary versus secondary outcomes, athlete studies, safety and funding.
Read the articleGHK-Cu · Skin, repair & translation
GHK-Cu explained: collagen and matrix-remodeling mechanisms, topical wound and cosmetic trials, skin penetration, and why systemic injection claims remain a separate question.
Read the articleMirabegron & brown fat · Human evidence
Mirabegron and brown fat: human thermogenesis trials, receptor uncertainty, glucose benefits, actual fat-loss outcomes and cardiovascular trade-offs in a visual evidence guide.
Read the articleAnastrozole & TRT · Human evidence
A visual review of anastrozole on TRT: aromatase, estradiol testing, symptoms, body composition, sexual function, bone and insulin sensitivity—with human trial limits.
Read the articlehCG & TRT · Fertility and human evidence
How hCG on TRT affects intratesticular testosterone, sperm, fertility, testicular size and well-being—and why neurosteroid claims need stronger human evidence.
Read the articleEnclomiphene & testosterone · Human evidence
A visual comparison of enclomiphene and testosterone: endogenous restoration versus replacement, LH, FSH, sperm, symptoms, muscle outcomes, safety and regulatory status.
Read the articleDHT & muscle · Human evidence
A visual review of dihydrotestosterone: androgen-receptor potency, tissue metabolism, direct human trials, muscle and fat outcomes, sexual function, prostate, hair and bone.
Read the articleBody composition · Investigational evidence
A visual review of bimagrumab with semaglutide: activin-receptor biology, BELIEVE trial fat and lean mass results, strength, safety and what remains unproven.
Read the articleIGF-1 & hypertrophy · Human evidence
IGF-1 signaling, satellite cells, acute human protein synthesis and longer trials: what Increlex can tell us about hypertrophy, and where healthy-adult evidence is missing.
Read the articleUrolithins & muscle · Mechanisms to human evidence
A visual comparison of urolithin A and B: mitophagy, muscle-growth mechanisms, human pharmacokinetics, conjugates, performance trials, potential health benefits and safety.
Read the articleMitochondrial peptides · Human evidence
A visual comparison of elamipretide (SS-31) and MOTS-c: cardiolipin, stress signaling, human trials, FDA approval, exercise claims and the evidence missing from peptide stacks.
Read the articleNandrolone & joint health · Human evidence
A visual review of nandrolone and joint pain: the small human studies, muscle and bone effects, conflicting tendon experiments, safety, and why pain relief is not proof of repair.
Read the articleRegenerative peptides · Translational evidence
A visual review of BPC-157, thymosin beta-4 and TB-500: mechanisms, human data, product identity, safety, and the trial needed to prove injury healing.
Read the articleMK-677 & growth hormone · Human evidence
A visual review of MK-677 (ibutamoren): GH and IGF-1, lean mass versus muscle and strength, appetite, weight, fluid, glucose, safety and the human trials.
Read the articleOxandrolone & muscle · Human evidence
A visual review of oxandrolone (Anavar): muscle, strength and body-composition trials, burn and wasting evidence, lipids, liver risk, suppression and current U.S. regulatory status.
Read the articleFatigue & performance · Clinical evidence
A visual guide to persistent fatigue when routine labs look normal: sleepiness, iron without anemia, underfueling, training load, hormones, medications and energy compounds.
Read the articleGrowth hormone & hypertrophy · Human evidence
A visual guide to growth hormone, lean mass and hypertrophy: water versus muscle, collagen versus myofibrillar protein, strength, performance, deficiency and risk.
Read the articleGH-axis peptides · Human evidence
A visual comparison of tesamorelin, ipamorelin and CJC-1295: receptors, exposure, visceral-fat trials, GH and IGF-1 biomarkers, stacking claims and safety.
Read the articleLongevity science · Human evidence
Do NAD supplements work? A visual guide to human trials of NR, NMN and NAD infusions: exercise, insulin sensitivity, brain health, safety and healthy aging.
Read the articleSleep & recovery · Compound evidence
Magnesium, glycine, theanine, apigenin and melatonin: what human trials show about sleep onset, staying asleep, next-day function and the limits of stacking.
Read the articleLipids & performance · Cardiovascular evidence
A visual guide to LDL-C, ApoB, Lp(a), cumulative exposure, zero calcium scores, testosterone and AAS, plus the outcome trials behind lipid-lowering treatments.
Read the articleEvidence guide · Muscle & hormones
What testosterone trials show about muscle growth, TRT and boosters, plus why glycogen, water and measurement methods complicate lean-mass gains.
Read the articleEvidence history · Metabolic medicine
The development of retatrutide, from cell and animal experiments to human trial results, body composition, safety, bariatric surgery comparisons and the regulatory timeline.
Read the articleAndrogens & endocrine pharmacology
Human methenolone studies, anecdotal bloodwork, TRT-plus hypotheses and the US prescribing and compounding differences between Primobolan and Anavar.
Read the articleMetabolic health & the brain
A close look at randomized alcohol trials, psychiatric safety, emotional blunting and what the evidence means for semaglutide, tirzepatide and retatrutide.
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