The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.

Studied

Randomized trial comparing weekly testosterone enanthate or placebo, each with or without standardized resistance training.

Who / model

Forty-three normal men received 600 mg testosterone enanthate or placebo weekly for 10 weeks; exercise groups lifted three times weekly.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Testosterone plus exercise increased fat-free mass by 6.1 kg; bench-press strength rose 22 kg and squat capacity 38 kg. Testosterone without exercise also outperformed placebo for measured muscle size and strength. Mood and behavior were unchanged.

Limits

This was a small, 10-week study in normal men using a supraphysiologic regimen. The abstract reports mood and behavior but no longer-term safety assessment or author-stated limitations.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary