SOURCE-LINKED STUDY SUMMARY
Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men.
Abstract summarizedQuality not appraised
- What was studied
- A 180-day active-comparator study evaluated transdermal testosterone gel effects on sexual function, mood, strength, DXA body composition, and safety in hypogonadal men.
- Who / model studied
- The study included 227 men with hypogonadism.
- Studied dose & schedule
- Men used 1% testosterone gel at 50 or 100 mg/day, adjustable to 75 mg/day at day 90, or a 5 mg/day permeation-enhanced testosterone patch.
- What the study found
- At 90 days, lean mass increased 2.74 kg with 100 mg gel versus 1.28 kg with 50 mg and 1.20 kg with patch. Leg-press strength increased 11–13 kg across groups. Gel reduced fat mass; hematocrit, hemoglobin, and PSA rose.
- Limitations & context
- This abstract assessment reports no placebo group. DXA lean mass is not direct muscle-size measurement, and the dose-adjustment design complicates fixed-dose comparisons.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1210/jcem.85.8.6747