SOURCE-LINKED STUDY SUMMARY
Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study.
Abstract summarizedQuality not appraised
- What was studied
- A randomized trial tested whether testosterone could improve strength, body composition, physical function, symptoms, and quality of life in frail older men with low or borderline-low testosterone.
- Who / model studied
- Two hundred seventy-four community-dwelling men who were intermediate-frail or frail and had low or borderline-low testosterone were randomized.
- Studied dose & schedule
- Participants used transdermal testosterone gel at the tested daily dose or placebo gel for six months.
- What the study found
- Knee-extension peak torque improved by 8.6 Newton-meters versus placebo. Lean mass increased 1.08 kg and fat mass decreased 0.9 kg in the testosterone group; function improved particularly among older, frailer participants.
- Limitations & context
- This was a single-center, six-month study in older frail men. The abstract does not report adverse-event results, and DXA lean mass is not a direct measure of muscle hypertrophy.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1210/jc.2009-1251