SOURCE-LINKED STUDY SUMMARY
Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle.
Abstract summarizedQuality not appraised
- What was studied
- A randomized, double-blind human trial tested testosterone dose responses, with comparison against previously studied younger men.
- Who / model studied
- Sixty healthy men aged 60–75 with normal testosterone were randomized; 52 completed treatment. Earlier comparison data covered 61 men aged 19–35.
- Studied dose & schedule
- After suppression of endogenous testosterone, participants received testosterone enanthate at 25, 50, 125, 300, or 600 mg weekly for 20 weeks.
- What the study found
- Fat-free mass and strength increased with dose, with similar responses across ages. Mood and visuospatial cognition did not significantly change. High hematocrit, leg swelling, and prostate events were numerically more frequent in older men.
- Limitations & context
- The age comparison used previous younger-men data rather than concurrent age groups. No author-stated limitation was available in this abstract.
Read summary source ↗ · Prepared 9/23/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1210/jc.2004-1184