PEDEvidence

SOURCE-LINKED STUDY SUMMARY

"Anabolic" effects of methandienone in men undergoing athletic training.

Lancet (London, England) ·

Human

What was studied?

A double-blind crossover experiment examined whether methandienone (Dianabol) changed body composition, strength, performance and endocrine function during weight training.

What changed?

Body weight, lean mass and muscle size increased with methandienone. Strength and performance improved during both training periods, without a significant drug–placebo difference. Plasma testosterone decreased, while plasma cortisol and urinary cortisol excretion increased.

Who was studied?

The study involved 11 athletic men undertaking a course of weight training.

Studied exposure

Methandienone was given at 100 mg/day for 6 weeks, with a placebo period for comparison. The abstract does not specify administration route.

What remains uncertain?

The authors could not establish whether the body-composition changes reflected an anabolic effect or increased intracellular fluid.

Abstract summarized · Quality not appraised

Review record & corrections

Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.

No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.

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Research findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.

Original publication ↗ · DOI: 10.1016/s0140-6736(76)90001-5

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