SOURCE-LINKED STUDY SUMMARY
Effect of testosterone addition to nutrition and exercise on muscle mass in men with cirrhosis: the next trial.
Abstract summarizedQuality not appraised
- What was studied
- A randomized trial tested testosterone added to nutrition and exercise for cirrhosis-associated muscle wasting.
- Who / model studied
- 127 patients with cirrhosis and sarcopenia; 102 completed the 24-week study.
- Studied dose & schedule
- Testosterone undecanoate 1000 mg intramuscularly at weeks 0, 6, 12, 16, 20 and 24, plus nutrition/exercise, versus nutrition/exercise alone.
- What the study found
- In intention-to-treat analysis, 64.1% versus 25.3% achieved at least 10% improvement in appendicular muscle index. Frailty improved; no apparent major adverse events were reported.
- Limitations & context
- Abstract-based assessment. No placebo comparator was described; attrition and incomplete safety detail matter. Disease-specific DEXA results cannot establish healthy-lifter hypertrophy or long-term safety.
Read summary source ↗ · Prepared 10/15/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1007/s12072-026-11106-3