Testosterone dose-response relationships in healthy young men.

Studied

A randomized dose-response experiment compared five testosterone-enanthate groups over 20 weeks after suppressing participants' natural testosterone production. Energy and protein intake were standardized.

Who / model

61 healthy men aged 18–35 participated; all received a hormone-suppressing treatment plus one of the testosterone regimens.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Fat-free mass increased 3.4, 5.2 and 7.9 kg in the three higher-dose groups. Higher testosterone concentrations correlated with greater muscle size, strength, power and hemoglobin, but lower HDL cholesterol. Sexual function, cognition, mood and prostate-specific antigen did not significantly change.

Limits

No author-stated limitations were available in the abstract. This was a 20-week experiment with experimentally suppressed natural testosterone, rather than an untreated comparison.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary