SOURCE-LINKED STUDY SUMMARY
Testosterone dose-response relationships in healthy young men.
Abstract summarizedQuality not appraised
- What was studied
- A randomized dose-response experiment compared five testosterone-enanthate groups over 20 weeks after suppressing participants' natural testosterone production. Energy and protein intake were standardized.
- Who / model studied
- 61 healthy men aged 18–35 participated; all received a hormone-suppressing treatment plus one of the testosterone regimens.
- Studied dose & schedule
- For 20 weeks, 61 healthy young men received monthly injections of a gonadotropin-releasing hormone agonist to suppress their own testosterone production and were randomized to weekly injections of 25, 50, 125, 300, or 600 mg testosterone enanthate. The abstract does not specify the testosterone injection route or a placebo arm.
- What the study found
- Fat-free mass increased 3.4, 5.2 and 7.9 kg in the three higher-dose groups. Higher testosterone concentrations correlated with greater muscle size, strength, power and hemoglobin, but lower HDL cholesterol. Sexual function, cognition, mood and prostate-specific antigen did not significantly change.
- Limitations & context
- No author-stated limitations were available in the abstract. This was a 20-week experiment with experimentally suppressed natural testosterone, rather than an untreated comparison.
Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1152/ajpendo.2001.281.6.e1172