SOURCE-LINKED STUDY SUMMARY
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men.
Abstract summarizedQuality not appraised
- What was studied
- A muscle-biopsy analysis examined whether testosterone-associated fiber growth accompanies increases in satellite cells and muscle-fiber nuclei.
- Who / model studied
- Men underwent thigh-muscle biopsies before and after treatment; the abstract does not report the participant count.
- Studied dose & schedule
- Testosterone enanthate 125, 300 or 600 mg weekly for 20 weeks with a GnRH agonist; route was not specified in the abstract.
- What the study found
- At 300 and 600 mg weekly, satellite-cell percentages increased from 2.5% to 5.0% and 15.0%, respectively. Muscle-fiber nuclei also increased, linking hypertrophy with cellular remodeling.
- Limitations & context
- These are associated cellular changes; the analysis does not establish that satellite-cell increases caused hypertrophy or persisted after treatment.
Read summary source ↗ · Prepared 9/25/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1152/ajpendo.00370.2002