Explore cardiovascular safety signals without treating case reports, observational associations and randomized safety trials as interchangeable.
Selected from the completed-summary collection, not a systematic review or exhaustive literature search. Human reports appear first; reviews and preclinical work retain their labels.
Search, filter and compare →A single-center randomized trial compared one year of oxandrolone with placebo after severe burns, with follow-up for up to four years after therapy. Exercise versus standard care was separately randomized.
No author-stated limitations were available in the abstract. This was a single-center pediatric burn study, with exercise also influencing muscle outcomes.
Randomized trial comparing daily testosterone gel with placebo for 6 months, with adverse events and physical performance assessed.
The authors cautioned that the small trial and its medically complex, mobility-limited population prevent broad conclusions about testosterone safety.
An observational study examined relationships between testosterone, gender-minority stress and blood-pressure responses to brief physical and psychological stress.
Study limitations were not stated in the abstract. Methodological quality has not been appraised.
A case report described severe heart failure alongside nonprescription testosterone and aromatase-inhibitor use and an underlying genetic finding.
Study limitations were not stated in the abstract. Methodological quality has not been appraised.
This Endocrine Society clinical-practice guideline addressed evaluation and treatment of androgen-deficiency syndromes in adult men.
The panel advised against starting therapy with breast or prostate cancer, high hematocrit, severe untreated sleep apnea, severe urinary symptoms, or poorly controlled heart failure.