PEDEvidence@pedevidence

SOURCE-LINKED STUDY SUMMARY

Fall of the Titans: Anabolic-Androgenic Steroid Use in a Patient With a TTN Truncating Variant.

JACC. Case reports ·

Human

Abstract summarizedQuality not appraised
What was studied
A case report described severe heart failure alongside nonprescription testosterone and aromatase-inhibitor use and an underlying genetic finding.
Who / model studied
One 35-year-old man with acute breathlessness reported use over the preceding year. No comparison group or follow-up duration is stated.
Studied dose & schedule
Dose and schedule have not yet been extracted for this summary.
What the study found
Heart imaging showed an ejection fraction of 25%. Genetic testing identified a pathogenic variant associated with the patient's dilated cardiomyopathy. This describes coexisting exposures and genetic susceptibility.
Limitations & context
Study limitations were not stated in the abstract. Methodological quality has not been appraised.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary

Review record & corrections

Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.

No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.

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Research findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.

Original publication ↗ · DOI: 10.1016/j.jaccas.2026.110248

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