PEDEvidence

SOURCE-LINKED STUDY SUMMARY

Fall of the Titans: Anabolic-Androgenic Steroid Use in a Patient With a TTN Truncating Variant.

JACC. Case reports ·

Human

Abstract summarized · Quality not appraised
Studied
A case report described severe heart failure alongside nonprescription testosterone and aromatase-inhibitor use and an underlying genetic finding.
Who / model
One 35-year-old man with acute breathlessness reported use over the preceding year. No comparison group or follow-up duration is stated.
Studied dose & schedule
Dose and schedule have not yet been extracted for this summary.
Found
Heart imaging showed an ejection fraction of 25%. Genetic testing identified a pathogenic variant associated with the patient's dilated cardiomyopathy. This describes coexisting exposures and genetic susceptibility.
Limits
Study limitations were not stated in the abstract. Methodological quality has not been appraised.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary

Research findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.

Original publication ↗ · DOI: 10.1016/j.jaccas.2026.110248

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