Adverse events associated with testosterone administration.

Studied

Randomized trial comparing daily testosterone gel with placebo for 6 months, with adverse events and physical performance assessed.

Who / model

The trial enrolled 209 community-dwelling men aged at least 65 with mobility limitations and low testosterone; mean age was 74, with substantial chronic disease.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

The trial stopped early after more cardiovascular-related adverse events with testosterone: 23 men versus 5 with placebo. Testosterone improved leg-press and chest-press strength and loaded stair climbing.

Limits

The authors cautioned that the small trial and its medically complex, mobility-limited population prevent broad conclusions about testosterone safety.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary