Effects of Testosterone Treatment in Older Men.

Studied

Three linked trials compared testosterone gel with placebo for one year, assessing sexual function, walking performance and vitality.

Who / model

790 symptomatic men aged 65 or older had low testosterone concentrations.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Sexual activity, desire and erectile function improved. The main walking outcome did not improve in the Physical Function Trial, but a pooled analysis across all three trials favored testosterone. Vitality did not significantly improve; mood and depressive symptoms improved slightly. Adverse-event rates were similar.

Limits

The authors stated that too few participants were enrolled to draw conclusions about treatment risks. The results concern older symptomatic men with low testosterone.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary