SOURCE-LINKED STUDY SUMMARY
Mapping sex-specific hormone–metabolite coupling in the adolescent brain: a longitudinal whole-brain spectroscopic imaging study
Abstract summarizedQuality not appraised
- What was studied
- An observational study tracked associations between blood steroid hormones and brain chemistry during adolescence.
- Who / model studied
- Forty-two healthy adolescents aged 13–15, including 24 girls, contributed 100 brain-scan visits and repeated hormone measurements. Total follow-up duration is not stated.
- Studied dose & schedule
- Dose and schedule have not yet been extracted for this summary.
- What the study found
- In boys, rising testosterone tracked increases in frontal glutamate/glutamine and a neuronal metabolic marker. In girls, higher average estradiol correlated with more frontal choline compounds. Cortisone-related associations differed by sex. These are associations, not demonstrated hormone-treatment effects.
- Limitations & context
- Study limitations were not stated in the abstract. Methodological quality has not been appraised.
Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.64898/2026.09.07.749851