Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate.

What was studied

This double-blind crossover trial tested whether raising endogenous testosterone with clomiphene improved erectile and sexual function in men with secondary hypogonadism.

Who / model studied

Seventeen men had erectile dysfunction and laboratory evidence of secondary hypogonadism.

Studied dose & schedule

Each participant received clomiphene and placebo for two months apiece in crossover fashion. The abstract did not state the clomiphene dose or route.

What the study found

Clomiphene significantly raised LH, FSH, total testosterone and free testosterone relative to placebo, but sexual function did not generally improve; limited parameters improved in younger, healthier men.

Limitations & context

The sample was small, dose was not reported in the abstract, and subgroup signals were limited. Higher hormone levels did not establish reversal of erectile dysfunction.

Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary