Rethinking gonadotropin releasing hormone agonist suppression test: why it should be a gonadotropin releasing hormone antagonist suppression test.

Studied

A hypothesis paper proposing GnRH antagonists instead of agonists for diagnostic sex-hormone suppression testing.

Who / model

No patient cohort or experiment is reported in the abstract. The article develops a physiological and pharmacological proposal.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

The authors expect antagonists to block receptors immediately and suppress pituitary gonadotropins rapidly, while testosterone and estradiol would fall more slowly because they still require synthesis changes and clearance.

Limits

The proposal has not been prospectively validated, and the best time to remeasure downstream hormones is unknown.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary