4-Phenylbutyric acid alleviates acrylamide-induced sexual behavioral deficits and testicular damage in male Wistar rats: modulation of ER-stress associated signaling.

Studied

Whether 4-phenylbutyric acid reduced reproductive damage caused by acrylamide exposure in male rats.

Who / model

Thirty-two adult male rats were split into four groups of eight. Acrylamide was given for 28 days, with 4-phenylbutyric acid added during the final 14 days in two groups.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Acrylamide reduced sperm count and testosterone and damaged sexual behavior and testicular tissue. Treatment improved these measures and reduced markers related to cellular stress.

Limits

This was an acrylamide-toxicity experiment in rats. It does not establish fertility, testosterone or sexual-performance benefits in healthy humans.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary