Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.

Studied

Two randomized, double-blind, double-dummy phase III studies compared two oral enclomiphene doses with topical testosterone gel; the studies were placebo-controlled.

Who / model

Participants were overweight men aged 18-60 with secondary hypogonadism and repeatedly measured early-morning total testosterone no higher than 300 ng/dL. The abstract does not state the sample size.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

After 16 weeks, total testosterone increased in all treatment groups. LH and FSH rose with enclomiphene but fell with testosterone gel; sperm concentration remained normal with enclomiphene and fell markedly with gel.

Limits

The abstract provides no group sizes, dose-specific effect magnitudes, adverse-event results or author-stated limitations, restricting safety and precision assessment.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary