SOURCE-LINKED STUDY SUMMARY
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.
Abstract summarizedQuality not appraised
- What was studied
- Two randomized, double-blind, double-dummy phase III studies compared two oral enclomiphene doses with topical testosterone gel; the studies were placebo-controlled.
- Who / model studied
- Participants were overweight men aged 18-60 with secondary hypogonadism and repeatedly measured early-morning total testosterone no higher than 300 ng/dL. The abstract does not state the sample size.
- Studied dose & schedule
- Dose and schedule have not yet been extracted for this summary.
- What the study found
- After 16 weeks, total testosterone increased in all treatment groups. LH and FSH rose with enclomiphene but fell with testosterone gel; sperm concentration remained normal with enclomiphene and fell markedly with gel.
- Limitations & context
- The abstract provides no group sizes, dose-specific effect magnitudes, adverse-event results or author-stated limitations, restricting safety and precision assessment.
Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1111/bju.13337