SOURCE-LINKED STUDY SUMMARY
Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial.
What was studied?
A randomized trial tested whether blocking testosterone conversion to DHT changes gains in fat-free mass and strength.
What changed?
Dutasteride did not significantly alter dose-adjusted fat-free-mass gains or strength changes. Conversion to DHT was not necessary for testosterone’s anabolic response under these study conditions.
Who was studied?
139 healthy men aged 18 to 50 were randomized; 102 completed treatment.
Studied exposure
Testosterone enanthate 50, 125, 300 or 600 mg weekly for 20 weeks, plus dutasteride 2.5 mg daily or placebo; routes were not specified in the abstract.
What remains uncertain?
Only 102 of 139 randomized men completed the 20-week intervention. These short-term results do not establish long-term equivalence or safety.
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1001/jama.2012.227