SOURCE-LINKED STUDY SUMMARY
Six-week improvements in muscle mass and strength during androgen therapy in older men.
What was studied?
A randomized placebo-controlled study examined early changes in muscle mass, strength, leg power and physical function during oxandrolone treatment.
What changed?
At six weeks, lean mass increased 2.7 kg with oxandrolone versus a 0.5 kg decline with placebo. Strength improved across four exercises. Leg muscle power and walking speed did not improve.
Who was studied?
Thirty-two older men, averaging 72 years of age, were assigned two-to-one to oxandrolone or placebo.
Studied exposure
Oxandrolone 10 mg twice daily or matching placebo for 12 weeks; early outcomes were assessed at six weeks. Administration route was not stated.
What remains uncertain?
Study limitations were not stated in the abstract. Methodological quality has not been appraised.
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1093/gerona/60.12.1586