SOURCE-LINKED STUDY SUMMARY
Effects of androgen therapy on adipose tissue and metabolism in older men.
What was studied?
A randomized trial examined oxandrolone's effects on regional body fat and metabolic markers in older men.
What changed?
Body fat declined and an insulin-sensitivity estimate improved. Twelve weeks after stopping, 83% of total, trunk and limb fat reductions persisted. However, HDL cholesterol fell 0.49 mmol/L, LDL rose 0.57 mmol/L and non-HDL rose 0.54 mmol/L during treatment; lipid changes were largely reversible.
Who was studied?
Thirty-two men aged 60–87 participated: 20 received oxandrolone and 12 received matching placebo.
Studied exposure
Oxandrolone 20 mg daily or placebo for 12 weeks. Route and daily dose-splitting were not specified in the abstract.
What remains uncertain?
Study limitations were not stated in the abstract. Methodological quality has not been appraised.
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1210/jc.2004-0784