SOURCE-LINKED STUDY SUMMARY
Microbial-Derived Exerkines Outperform Creatine Monohydrate in Enhancing Skeletal Muscle Adaptation to Exercise in Mice.
Abstract summarizedQuality not appraised
- What was studied
- A mouse experiment compared microbial metabolites with creatine during exercise training.
- Who / model studied
- Mice; sample size, strain and sex were not specified in the abstract.
- Studied dose & schedule
- Pipecolic acid plus succinate, creatine or vehicle during a 7-week weighted-wheel training protocol; dose and route not reported in the abstract.
- What the study found
- Both interventions improved high-intensity running versus vehicle. The metabolite combination increased grip strength and isolated-muscle force beyond creatine. Neither increased lean mass, muscle mass or soleus fiber size versus vehicle.
- Limitations & context
- Animal findings cannot establish a human creatine replacement. Strength improved without demonstrated hypertrophy. Effect sizes and safety were unavailable in the abstract.
Read summary source ↗ · Prepared 10/15/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1152/ajpcell.00431.2026