Mitochondrial homeostasis in musculoskeletal diseases: From pathogenic mechanisms to precision therapies.

Studied

A review of mitochondrial dysfunction and potential targeted treatments in musculoskeletal disease.

Who / model

Preclinical and clinical research on bone, cartilage and muscle, especially osteoporosis, osteoarthritis and rheumatoid arthritis. This was a review, not a newly enrolled cohort.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

The review links impaired energy production, mitochondrial maintenance and oxidative balance with disease mechanisms. It discusses candidate approaches including MitoQ, metformin, NAD+ boosters and urolithin A.

Limits

The abstract proposes a treatment framework but reports no new comparative trial or compound-specific effect sizes. The discussed approaches remain a research landscape, not established benefits for every condition.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary