SOURCE-LINKED STUDY SUMMARY
Effects of nandrolone decanoate on lean body mass and anemia in adults with chronic kidney disease: a systematic review and meta-analysis.
Full paper summarizedQuality not appraised
- What was studied
- A full-text systematic review and meta-analysis combined randomized trials of intramuscular nandrolone decanoate versus placebo, standard care, erythropoietin, exercise or other controls in adults with chronic kidney disease.
- Who / model studied
- Fifteen trials included adults across dialysis and pre-dialysis settings. Four lean-mass trials included 125 participants, six hemoglobin trials included 239 and seven hematocrit trials included 198; treatment lasted 12 weeks to 12 months.
- Studied dose & schedule
- Dose and schedule have not yet been extracted for this summary.
- What the study found
- Across four trials, nandrolone increased lean body mass by 2.63 kg versus controls. Hemoglobin and hematocrit estimates favored nandrolone, but heterogeneity and very low certainty prevented firm conclusions. Quality-of-life findings were inconsistent, and androgenic, liver-enzyme and lipid effects were reported.
- Limitations & context
- Evidence was largely historical, most studies had bias concerns, patient-centered outcomes were sparse, and long-term safety data were limited.
Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: full paper. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1007/s12020-026-04771-9