SOURCE-LINKED STUDY SUMMARY
Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.
Full paper summarizedQuality not appraised
- What was studied
- This double-blind trial tested whether metformin alters cardiorespiratory, insulin-sensitivity and skeletal-muscle mitochondrial adaptations to aerobic training.
- Who / model studied
- Fifty-three older adults, averaging about 62 years and free of chronic disease but with at least one diabetes risk factor, received placebo or metformin.
- Studied dose & schedule
- Participants completed supervised aerobic training three times weekly for 12 weeks. Metformin began at 500 mg/day and rose weekly to 2,000 mg/day; lighter participants could receive 1,500 mg/day. Placebo was matched.
- What the study found
- Metformin inhibited the exercise-related gain in insulin sensitivity, attenuated the VO2max increase and abolished increases in mitochondrial respiration, although mitochondrial protein synthesis was similar between groups and responses varied.
- Limitations & context
- There was no metformin-only arm and insulin sensitivity was not measured with the gold-standard hyperinsulinemic-euglycemic clamp.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: full paper. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1111/acel.12880