SOURCE-LINKED STUDY SUMMARY
Effects of human growth hormone in men over 60 years old.
Abstract summarizedQuality not appraised
- What was studied
- A controlled study observed older men for six baseline months, then compared growth-hormone treatment with no treatment for six months.
- Who / model studied
- 21 healthy men aged 61–81 with low IGF-I participated: 12 received growth hormone and nine received no treatment.
- Studied dose & schedule
- For six months, 12 men received approximately 0.03 mg/kg of biosynthetic human growth hormone by subcutaneous injection three times weekly. Nine men received no treatment. These are the studied exposures in this older-men study, not a recommended regimen.
- What the study found
- In treated men, lean mass increased 8.8 percent, fat mass decreased 14.4 percent and lumbar-spine bone density increased 1.6 percent. Forearm and upper-femur bone density did not significantly change. Skin thickness increased, but the reported result was not statistically significant. Untreated men had no significant changes in these measures.
- Limitations & context
- No author-stated limitations or adverse-event results were available in the abstract. The comparator received no treatment; random allocation was not described.
Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1056/nejm199007053230101