SOURCE-LINKED STUDY SUMMARY
Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis.
Abstract summarizedQuality not appraised
- What was studied
- Human mechanistic study of growth hormone (GH), collagen synthesis and contractile-muscle protein synthesis.
- Who / model studied
- Healthy young adults; the supplied abstract does not specify sample size.
- Studied dose & schedule
- Recombinant human GH, 33–50 micrograms/kg/day for 14 days. Route and comparator are not described in the abstract.
- What the study found
- Tendon collagen synthesis increased 1.3-fold (P=0.02). Muscle collagen synthesis increased 5.8-fold, but was statistically uncertain (P=0.06). Myofibrillar protein synthesis was unchanged; moderate exercise did not amplify the GH effect.
- Limitations & context
- Abstract assessment of short-term synthesis endpoints, not established tendon healing or muscle growth. Adverse-event results are not reported in the abstract.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1113/jphysiol.2009.179325