Human
What does the prostate analysis leave unresolved?
Topical gel versus placebo; 5,204 men analyzed.
Demonstrated findings
High-grade prostate cancer occurred in 5 of 2,596 testosterone-treated men and 3 of 2,602 placebo-treated men. The difference was not statistically significant; PSA rose more with testosterone.
Limitations & adverse findings
This is a TRAVERSE analysis, sharing its registration with the cardiovascular report.
What might this mean? · interpretation
Low event counts in screened men support a limited conclusion, not proof of no long-term prostate risk.
What might this mean, and what would change the interpretation?
Participants at high prostate-cancer risk were excluded. Few events and limited follow-up constrain precision.
What would clarify this: Longer follow-up and evidence in populations excluded from this trial.
Findings reviewed · abstract
Checked Sep 15, 2026 against the linked abstract. This reading note is not a formal risk-of-bias appraisal.