How did dose and achieved levels relate to muscle outcomes?
20 weeks; weekly enanthate with a GnRH agonist. These are experimental regimens.
Across graded testosterone exposures, fat-free mass, muscle size and strength increased with dose. Mood and sexual function did not significantly change at any dose.
| Studied dose | Mean trough total T | Fat-free mass change |
|---|---|---|
| 125 mg/week | 542 ng/dL | +3.4 kg |
| 300 mg/week | 1,345 ng/dL | +5.2 kg |
| 600 mg/week | 2,370 ng/dL | +7.9 kg |
Group averages at the studied regimens, not a dosing recommendation or prediction of personal gains.
Hemoglobin increased and HDL cholesterol decreased with higher concentrations. Fat-free mass includes more than muscle.
Different outcomes can respond differently to increasing hormone exposure.
What might this mean, and what would change the interpretation?
61 healthy men aged 18–35; endogenous production was suppressed. Short-term group averages cannot predict an individual response.
What would clarify this: Longer trials measuring function and adverse outcomes across comparable exposures.
Findings reviewed · abstract
Checked Sep 15, 2026 against the linked abstract. This reading note is not a formal risk-of-bias appraisal.