Does testosterone treatment improve memory?
Daily gel versus placebo for 1 year; men aged 65 or older.
In the 493-person memory-impaired subgroup, testosterone did not significantly improve verbal memory, visual memory, executive function or spatial ability versus placebo.
This report shares the Testosterone Trials registration with other reports; it is not an independent trial population.
Improved hormone levels did not translate into cognitive gains on these tests.
What might this mean, and what would change the interpretation?
Older men with low testosterone and age-associated memory impairment; this does not resolve every cognitive question in younger adults.
What would clarify this: Replication in different populations using prespecified cognitive and daily-function outcomes.
Findings reviewed · abstract
Checked Sep 15, 2026 against the linked abstract. This reading note is not a formal risk-of-bias appraisal.