Human
What did semaglutide achieve in the direct comparison?
13.7% weight reduction72 weeks; maximum tolerated semaglutide 1.7/2.4 mg versus tirzepatide 10/15 mg; adults without diabetes.
Demonstrated findings
Participants assigned semaglutide lost an average of 13.7% of body weight at 72 weeks, versus 20.2% with tirzepatide.
What might this mean? ยท interpretation
Semaglutide produced substantial weight reduction in this trial, with a smaller average reduction than the comparator.
What might this mean, and what would change the interpretation?
This result applies to the studied regimens and population. Weight change does not establish preservation of muscle or long-term cardiovascular benefit.
What would clarify this: Endpoint-specific comparisons using matched populations and durations.