Human
What did the direct comparison with liraglutide show?
15.8% weight reduction338 adults; semaglutide 2.4 mg weekly versus liraglutide 3 mg daily.
Demonstrated findings
Mean weight reduction was 15.8% with semaglutide and 6.4% with liraglutide at 68 weeks.
Limitations & adverse findings
Gastrointestinal events were common in both groups.
What might this mean? · interpretation
This directly compares the two studied regimens for weight loss.
What might this mean, and what would change the interpretation?
Open-label comparison in adults without diabetes; other doses and outcomes need separate evidence.
What would clarify this: Longer follow-up and matched body-composition outcomes.
Findings reviewed · abstract
Checked Sep 15, 2026 against the linked abstract. This reading note is not a formal risk-of-bias appraisal.