Human
How did liraglutide perform in STEP 8?
6.4% weight reductionDaily liraglutide 3 mg versus weekly semaglutide 2.4 mg.
Demonstrated findings
Mean weight reduction was 6.4%, versus 15.8% with semaglutide at 68 weeks.
Limitations & adverse findings
Treatment discontinuation for any reason: 27.6% versus 13.5% with semaglutide.
What might this mean? · interpretation
Liraglutide produced weight loss, with a smaller average change in this direct comparison.
What might this mean, and what would change the interpretation?
These results apply to the tested regimens in adults without diabetes.
What would clarify this: Comparisons of outcomes beyond body weight.
Findings reviewed · abstract
Checked Sep 15, 2026 against the linked abstract. This reading note is not a formal risk-of-bias appraisal.