SOURCE-LINKED STUDY SUMMARY
Large increases in resistance training volume do not impair muscle hypertrophy or anabolic-catabolic molecular signaling in trained individuals.
Abstract summarizedQuality not appraised
- What was studied
- A randomized within-person trial compared large versus modest increases in resistance-training volume.
- Who / model studied
- Twenty-five resistance-trained men and women; each participant trained both legs.
- Studied dose & schedule
- One leg received a 120% volume increase, the other 20%, relative to habitual training, twice weekly for 8 weeks.
- What the study found
- Both protocols increased ultrasound-measured muscle cross-sectional area, without a significant difference between protocols. Muscle-fiber size and most molecular responses also did not differ.
- Limitations & context
- Abstract-based assessment. Small, short unilateral study; absence of a difference does not establish equivalence or an optimal volume for all muscles and trainees.
Read summary source ↗ · Prepared 10/15/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1152/japplphysiol.00284.2026