SOURCE-LINKED STUDY SUMMARY
MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.
What was studied?
Researchers examined whether and how MOTS-c affects skeletal-muscle mitochondrial function, focusing on dependence on the PGC-1α regulator and AMPK energy-sensing enzyme.
What changed?
Mouse muscle mitochondrial performance improved, with lower reactive oxygen release and related protein damage, but no apparent change in respiratory protein content. In humans, interstitial MOTS-c increased during exercise, but its arterial–venous difference did not change. These human observations do not test MOTS-c treatment efficacy.
Who was studied?
Experiments used two transgenic mouse strains. A separate human experiment examined one-legged knee-extension exercise; sample sizes were not reported in the abstract.
Studied exposure
MOTS-c was administered in the mouse experiments. The abstract does not specify dose, route, treatment duration or comparator details.
What remains uncertain?
Study limitations were not stated in the abstract. Methodological quality has not been appraised.
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1016/j.freeradbiomed.2026.01.002