SOURCE-LINKED STUDY SUMMARY
MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.
Abstract summarizedQuality not appraised
- What was studied
- Researchers examined whether and how MOTS-c affects skeletal-muscle mitochondrial function, focusing on dependence on the PGC-1α regulator and AMPK energy-sensing enzyme.
- Who / model studied
- Experiments used two transgenic mouse strains. A separate human experiment examined one-legged knee-extension exercise; sample sizes were not reported in the abstract.
- Studied dose & schedule
- MOTS-c was administered in the mouse experiments. The abstract does not specify dose, route, treatment duration or comparator details.
- What the study found
- Mouse muscle mitochondrial performance improved, with lower reactive oxygen release and related protein damage, but no apparent change in respiratory protein content. In humans, interstitial MOTS-c increased during exercise, but its arterial–venous difference did not change. These human observations do not test MOTS-c treatment efficacy.
- Limitations & context
- Study limitations were not stated in the abstract. Methodological quality has not been appraised.
Read summary source ↗ · Prepared 9/24/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1016/j.freeradbiomed.2026.01.002