SOURCE-LINKED STUDY SUMMARY
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.
Full paper summarizedQuality not appraised
- What was studied
- This translational study measured exercise-induced endogenous MOTS-c in humans and tested administered MOTS-c in mouse and cell models of physical capacity and metabolic stress.
- Who / model studied
- The human exercise experiment included 10 sedentary healthy young men. Treatment experiments used young, middle-aged, old and late-life mice, plus C2C12 myoblasts.
- Studied dose & schedule
- Middle-aged and old mice received MOTS-c 15 mg/kg/day intraperitoneally for 2 weeks before treadmill testing. Human participants received no MOTS-c.
- What the study found
- Human muscle MOTS-c rose 11.9-fold after exercise; circulating levels rose 1.6-fold during and 1.5-fold after exercise. Treated old mice ran 2-fold longer and 2.16-fold farther.
- Limitations & context
- No human participant received MOTS-c, so the study provides no human efficacy, dose or safety result for administered MOTS-c. Performance treatment findings were preclinical.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: full paper. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1038/s41467-020-20790-0