PEDEvidence

SOURCE-LINKED STUDY SUMMARY

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial.

JAMA network open ·

Human

Abstract summarized · Quality not appraised
Studied
A blinded, randomized trial tested urolithin A against placebo for walking ability, muscle endurance and cellular energy production.
Who / model
66 adults aged 65 to 90 took part in a 4-month trial.
Studied dose & schedule
Dose and schedule have not yet been extracted for this summary.
Found
Muscle endurance measures improved, but walking distance and the primary cellular-energy measure did not improve significantly versus placebo.
Limits
This was a small study, predominantly in women, and all participants were White. The authors called for further confirmation.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary

Research findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.

Original publication ↗ · DOI: 10.1001/jamanetworkopen.2021.44279

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