PEDEvidence

SOURCE-LINKED STUDY SUMMARY

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.

The New England journal of medicine ·

Human

Abstract summarized · Quality not appraised
Studied
Randomized trial comparing liraglutide with placebo alongside standard care, tracking cardiovascular death, nonfatal heart attack or stroke.
Who / model
9340 people with type 2 diabetes and high cardiovascular risk; median follow-up was 3.8 years.
Studied dose & schedule
Dose and schedule have not yet been extracted for this summary.
Found
The primary combined cardiovascular outcome occurred in 13.0% versus 14.9%. Cardiovascular deaths were 4.7% versus 6.0%. Individual nonfatal heart attacks, strokes and heart-failure admissions did not show statistically clear differences. Digestive problems were the most common reason for stopping liraglutide.
Limits
Exploratory outcomes were tested without adjustment for making multiple comparisons.

Read summary source ↗ · Prepared 9/16/2026 · AI-assisted, source-based summary

Research findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.

Original publication ↗ · DOI: 10.1056/nejmoa1603827

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