Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined.

Studied

This randomized, placebo-controlled trial compared exercise, liraglutide, their combination, and placebo for one year after an eight-week low-calorie diet.

Who / model

The study included 195 adults with obesity and no diabetes who had already lost an average 13.1 kg during the diet phase.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Compared with placebo, weight was lower by 4.1 kg with exercise, 6.8 kg with liraglutide, and 9.5 kg with both. Increased heart rate and gallstones occurred more often with liraglutide alone than with the combination.

Limits

The combination was not significantly better than liraglutide alone for weight loss, and results apply to post-diet adults without diabetes over one year.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary