Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial.

Studied

This 56-week randomized, double-blind trial compared daily liraglutide 3.0 mg, liraglutide 1.8 mg, and placebo; every group also received a calorie deficit and increased physical activity.

Who / model

The trial randomized 846 adults with overweight or obesity and type 2 diabetes at 126 sites in nine countries.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

At week 56, mean weight loss was 6.0%, 4.7%, and 2.0%, respectively. Gastrointestinal disorders were more common with 3.0 mg liraglutide; no pancreatitis was reported.

Limits

Only 12 weeks of off-drug observation followed treatment, and the authors called for longer-term efficacy and safety research.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary