PEDEvidence

SOURCE-LINKED STUDY SUMMARY

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management.

The New England journal of medicine ·

Human

Abstract summarized · Quality not appraised
Studied
Randomized trial comparing liraglutide with placebo for weight loss, with lifestyle counseling in both groups.
Who / model
3731 adults without type 2 diabetes, with obesity or overweight plus abnormal blood lipids or hypertension; treatment lasted 56 weeks.
Studied dose & schedule
Dose and schedule have not yet been extracted for this summary.
Found
All primary weight outcomes favored liraglutide: average loss was 8.4 versus 2.8 kg; 63.2% versus 27.1% lost at least 5%, and 33.1% versus 10.6% lost more than 10%. Mild or moderate nausea and diarrhea were common. Serious events occurred in 6.2% versus 5.0%.
Limits
The reported weight analysis filled missing values by carrying forward the last recorded observation.

Read summary source ↗ · Prepared 9/16/2026 · AI-assisted, source-based summary

Research findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.

Original publication ↗ · DOI: 10.1056/nejmoa1411892

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