SOURCE-LINKED STUDY SUMMARY
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Abstract summarizedQuality not appraised
- What was studied
- Discovery research identified MOTS-c, a mitochondrial peptide, and investigated its cellular actions and metabolic effects.
- Who / model studied
- Experiments included mice with aging-related or high-fat-diet-related insulin resistance. The abstract does not state sample sizes, comparators or treatment duration.
- Studied dose & schedule
- Dose and schedule have not yet been extracted for this summary.
- What the study found
- MOTS-c inhibited the folate cycle and linked purine synthesis, activating AMPK, a cellular energy-regulating pathway. Treatment prevented age-related and diet-induced insulin resistance and diet-induced obesity in mice. Skeletal muscle appeared to be a major target.
- Limitations & context
- No author-stated limitations were available in the abstract. These cellular and mouse findings do not establish human weight-loss effectiveness or safety.
Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1016/j.cmet.2015.02.009