SOURCE-LINKED STUDY SUMMARY
Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial.
Abstract summarizedQuality not appraised
- What was studied
- This double-blind randomized trial tested whether high-dose vitamins C and E altered adaptations to endurance training.
- Who / model studied
- Fifty-four young men and women completed an 11-week endurance-training intervention.
- Studied dose & schedule
- Participants received vitamin C 1000 mg plus vitamin E 235 mg or placebo daily while training three to four times weekly.
- What the study found
- Both groups improved VO₂max similarly. COX4 and PGC-1α increased in placebo but not vitamin recipients, indicating attenuated cellular markers of mitochondrial biogenesis without a detected performance penalty.
- Limitations & context
- The cellular differences did not translate into differences on the performance tests used. The abstract reports no adverse-event results.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1113/jphysiol.2013.267419