The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.

Studied

Mechanistic research compared tendon explants and cultured tendon fibroblasts with and without BPC 157 to investigate tendon-healing pathways.

Who / model

Experiments used rat Achilles-tendon-derived fibroblasts and tendon explants. The abstract does not report sample sizes or overall experiment duration.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

BPC 157 increased explant outgrowth, cell survival under oxidative stress, migration and spreading. It did not directly increase fibroblast proliferation. Activation of FAK and paxillin, proteins involved in cell adhesion and signaling, increased without a change in their total amounts.

Limits

No author-stated limitations were available in the abstract. These were tissue and cell experiments, not evidence of improved tendon healing or established safety in people.

Read summary source ↗ · Prepared 9/22/2026 · AI-assisted, source-based summary