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5-Amino-1MQ

Findings, possible implications, and reported experiences.

About 5-Amino-1MQ

Small moleculeMetabolism

Primary research area: Emerging research
Regulatory status: Research status varies
Evidence level: Evidence level not yet characterized
Primary mechanism: Mechanism not yet characterized

Reference profile available · Coverage varies by section

Also known as 5-amino-1-methylquinolinium

5-Amino-1MQ is an experimental inhibitor of nicotinamide N-methyltransferase, an enzyme involved in methyl-group metabolism. It is studied mainly as a metabolic research compound, not as an approved medicine. [1]

What has been observed?

Selected source-linked reading notes, not the complete literature or a pooled conclusion.

Animal · Reading scope not recorded

Why is NNMT inhibition interesting for metabolism?

5-Amino-1MQ inhibited NNMT in adipocytes; treatment reduced body weight and adiposity in a high-fat-diet mouse model.

Limits: The mouse findings do not establish human fat loss, oral exposure or a predictable human effect size.

Open primary source · Read interpretation separately

Explore outcomes for this compound

Uses & research: The cited primary research examined NNMT inhibition in adipocytes and in mice fed a high-fat diet. The study measured body weight, adiposity and metabolic features in that animal model; it did not test people. [1]
Known half-life: No source-verified value in this profile yet. A treatment schedule or duration of an effect is not a drug half-life.
Half-life describes how quickly the measured drug concentration falls by half. It does not set a dosing interval.
Evidence & important limits: The available source does not establish a human half-life, human exposure, human safety profile or predictable fat-loss effect. Findings in high-fat-diet mice cannot be generalized to healthy adults, and the study does not support dosing or performance claims. [1]

Safety & evidence boundaries

Source-specific information, not a personal safety clearance or monitoring plan.

The available source does not establish a human half-life, human exposure, human safety profile or predictable fat-loss effect. Findings in high-fat-diet mice cannot be generalized to healthy adults, and the study does not support dosing or performance claims.

NNMT inhibition in diet-induced obesity

Explore safety questions by system

These are literature filters, not claims that this compound causes each effect. A keyword match is not a confirmed adverse reaction.

Heart, blood pressure & lipids Liver injury Kidney function Glucose effects Reproductive & endocrine effects Mood & sleep Adverse effects & interactions

Interactions, rare harms, long-term effects and reversibility require separate evidence. Do not infer they are absent when the sources here do not address them.

Identity, names & formulations

Canonical compound: 5-Amino-1MQ · 5amino1mq

Searchable names: 5-amino-1-methylquinolinium

Names share a parent research page. Different esters, salts, routes and brands are not assumed to have the same half-life, indication or exposure.

Combination evidence stays attached to the studied combination. It is not automatically assigned to each ingredient.

Understand the evidence types

Read the model and design first, then the population, outcome and limitations. These categories describe evidence, not a best-compound ranking.

Randomized human trials: Compare assigned interventions. Randomization does not by itself establish low bias or relevance to every population.
Controlled human studies: Use a comparison group; allocation and confounding still matter.
Prospective human research: Follows participants forward. It may be observational or interventional, so this is not a separate quality grade.
Observational human research: Describes associations. Confounding can explain differences.
Case reports and series: Useful for unusual events and safety signals, not reliable rates or effect sizes.
Animal research: Can test biology and function in a living model. Human exposure, benefit and safety remain separate questions.
Cell and tissue research: Tests responses in a preparation, including human-derived cells. It is not a human participant trial.
Mechanistic and computational evidence: Helps explain or predict a pathway; predictions need experimental and clinical testing.
Anecdotal reports: Self-reported experiences can generate questions. Product identity, selection bias and other interventions may be uncontrolled.

Systematic reviews synthesize studies and depend on their quality. Preprint status and abstract versus full-paper reading are separate labels. Citation popularity measures attention, not reliability. A study summary is not a formal quality appraisal.

Sources for this profile

1. NNMT inhibition in diet-induced obesity Primary full article · adipocyte and mouse metabolic models

Reference facts checked 2026-09-16. Source scope is listed above; this is not a formal quality appraisal. See each label for full prescribing information.

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Research outcomeResearch model

Study model describes the source. Confidence depends on methods, replication, population and outcome.

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