5-Amino-1MQ is an experimental inhibitor of nicotinamide N-methyltransferase, an enzyme involved in methyl-group metabolism. It is studied mainly as a metabolic research compound, not as an approved medicine. The cited primary research examined NNMT inhibition in adipocytes and in mice fed a high-fat diet. The study measured body weight, adiposity and metabolic features in that animal model; it did not test people.[1.1]
Selected animal research: 5-Amino-1MQ inhibited NNMT in adipocytes; treatment reduced body weight and adiposity in a high-fat-diet mouse model. The mouse findings do not establish human fat loss, oral exposure or a predictable human effect size. A verified studied dose has not yet been added to this reading note.[2.1]
Studied methods, not dosing advice. Selected evidence, not a complete literature review or formal quality appraisal.
Source scope is listed with each reference. Prepared by PED Evidence with AI assistance. Independent clinician review has not been completed. Review standards
Study-summary coverage
No completed study summaries are linked to this compound page yet. This is a coverage gap on PED Evidence, not evidence that human studies or other research do not exist.
The cited primary research examined NNMT inhibition in adipocytes and in mice fed a high-fat diet. The study measured body weight, adiposity and metabolic features in that animal model; it did not test people. [1]
Known half-life
No source-verified value in this profile yet. A treatment schedule or duration of an effect is not a drug half-life.
Half-life describes how quickly the measured drug concentration falls by half. It does not set a dosing interval.
Evidence & important limits
The available source does not establish a human half-life, human exposure, human safety profile or predictable fat-loss effect. Findings in high-fat-diet mice cannot be generalized to healthy adults, and the study does not support dosing or performance claims. [1]
Safety & evidence boundaries
Source-specific information, not a personal safety clearance or monitoring plan.
The available source does not establish a human half-life, human exposure, human safety profile or predictable fat-loss effect. Findings in high-fat-diet mice cannot be generalized to healthy adults, and the study does not support dosing or performance claims.
Interactions, rare harms, long-term effects and reversibility require separate evidence. Do not infer they are absent when the sources here do not address them.
Identity, names & formulations
Canonical compound: 5-Amino-1MQ · 5amino1mq
Searchable names: 5-amino-1-methylquinolinium
Names share a parent research page. Different esters, salts, routes and brands are not assumed to have the same half-life, indication or exposure.
Combination evidence stays attached to the studied combination. It is not automatically assigned to each ingredient.
Understand the evidence types
Read the model and design first, then the population, outcome and limitations. These categories describe evidence, not a best-compound ranking.
Randomized human trials
Compare assigned interventions. Randomization does not by itself establish low bias or relevance to every population.
Controlled human studies
Use a comparison group; allocation and confounding still matter.
Prospective human research
Follows participants forward. It may be observational or interventional, so this is not a separate quality grade.
Observational human research
Describes associations. Confounding can explain differences.
Case reports and series
Useful for unusual events and safety signals, not reliable rates or effect sizes.
Animal research
Can test biology and function in a living model. Human exposure, benefit and safety remain separate questions.
Cell and tissue research
Tests responses in a preparation, including human-derived cells. It is not a human participant trial.
Mechanistic and computational evidence
Helps explain or predict a pathway; predictions need experimental and clinical testing.
Anecdotal reports
Self-reported experiences can generate questions. Product identity, selection bias and other interventions may be uncontrolled.
Systematic reviews synthesize studies and depend on their quality. Preprint status and abstract versus full-paper reading are separate labels. Citation popularity measures attention, not reliability. A study summary is not a formal quality appraisal.
Reference facts checked 2026-09-16. Source scope is listed above; this is not a formal quality appraisal. See each label for full prescribing information.