Comparative effects of central and peripheral PDE10A inhibition on weight gain following semaglutide cessation in diet-induced obese mice

Studied

Whether PDE10A inhibitors could limit weight gain, including after stopping semaglutide.

Who / model

Male mice with diet-induced obesity, in a 21-day dose-response experiment and a 40-day weight-maintenance experiment. The abstract does not state sample sizes.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Mardepodect suppressed food intake and weight gain, with results described as comparable to continued semaglutide. BEN-8744 limited gain in the dose-response experiment, but after semaglutide its advantage over vehicle was not statistically clear; glucose tolerance and insulin also did not clearly improve.

Limits

These mouse experiments do not establish weight-maintenance benefits in humans. The abstract does not report adverse-event results.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary