Side effects of lower dose compounded semaglutide paired with a behavioral management program: A real-world retrospective study

Studied

Whether a lower-dose compounded semaglutide program was associated with fewer reported side effects than a higher-dose program during the first 16 weeks.

Who / model

A retrospective real-world cohort of program users. The primary matched analysis included 2,481 users per group, and a second matched analysis included 958 per group.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

By week 16, the lower-dose program was associated with 34% lower odds of reported gastrointestinal side effects and 29% lower odds of any reported side effect. The second matched analysis also favored the lower-dose program.

Limits

This was retrospective and compared two compounded-drug programs paired with behavioral support. Association does not prove that dose alone caused the difference, and the abstract does not report weight-loss outcomes.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary