Semaglutide and Suicidality in Adults with Overweight or Obesity: A Bayesian Meta-Analysis of Randomized Trials

Studied

A meta-analysis compared semaglutide with placebo in adults with overweight or obesity, with or without type 2 diabetes. Death by suicide was primary; attempts, thoughts and overall suicidal events were secondary outcomes.

Who / model

Fifteen placebo-controlled trials contributed to at least one outcome. Follow-up durations are not stated in the abstract.

Studied dose & schedule

Dose and schedule have not yet been extracted for this summary.

Found

Eight trials reported 8 suicides among 17,086 semaglutide participants and 4 among 15,304 placebo participants. The analysis did not conclusively establish an increase or decrease in suicidality; estimates allowed meaningful effects in either direction.

Limits

The authors rated evidence certainty very low for every outcome because of imprecision and indirectness.

Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary