SOURCE-LINKED STUDY SUMMARY
Semaglutide and Suicidality in Adults with Overweight or Obesity: A Bayesian Meta-Analysis of Randomized Trials
Abstract summarizedQuality not appraised
- What was studied
- A meta-analysis compared semaglutide with placebo in adults with overweight or obesity, with or without type 2 diabetes. Death by suicide was primary; attempts, thoughts and overall suicidal events were secondary outcomes.
- Who / model studied
- Fifteen placebo-controlled trials contributed to at least one outcome. Follow-up durations are not stated in the abstract.
- Studied dose & schedule
- Dose and schedule have not yet been extracted for this summary.
- What the study found
- Eight trials reported 8 suicides among 17,086 semaglutide participants and 4 among 15,304 placebo participants. The analysis did not conclusively establish an increase or decrease in suicidality; estimates allowed meaningful effects in either direction.
- Limitations & context
- The authors rated evidence certainty very low for every outcome because of imprecision and indirectness.
Read summary source ↗ · Prepared 9/15/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.21203/rs.3.rs-10976576/v1