SOURCE-LINKED STUDY SUMMARY
MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.
Abstract summarizedQuality not appraised
- What was studied
- A randomized crossover study tested whether MK-677 could reverse negative nitrogen balance during calorie restriction.
- Who / model studied
- Eight healthy adults aged 24–39 years completed two calorie-restricted study periods.
- Studied dose & schedule
- During the final seven days of each 14-day diet period, participants received oral MK-677 25 mg or placebo once daily, separated by a 14–21-day washout.
- What the study found
- Daily nitrogen balance was +0.31 g/day with MK-677 versus −1.48 g/day with placebo. IGF-I also rose. The dose was generally well tolerated without clinically significant adverse experiences.
- Limitations & context
- This was an eight-person, seven-day exposure. Nitrogen balance is not direct evidence of preserved muscle size, strength, or long-term outcomes during dieting.
Read summary source ↗ · Prepared 10/6/2026 · AI-assisted, source-based summary
Review record & corrections
Summary prepared: . Source scope: abstract. This is an AI-assisted source summary, not an independent clinician sign-off.
No public field-by-field revision history is available for this card yet. The date above is the summary date, not proof that every field was updated then.
Inspect the source · Correction policyResearch findings apply to the population and conditions studied. This educational summary is not a treatment recommendation or a formal assessment of study quality.
Original publication ↗ · DOI: 10.1210/jcem.83.2.4551